Leventa oral solution is a readily accepted, easily administered, small-volume liquid formulation of levothyroxine sodium. It provides the thyroxine needed by dogs with hypothyroidism, plus the convenience dog owners want. Given once daily, Leventa is a convenient alternative to non-chewable oral tablets for treatment of canine hypothyroidism. 

Leventa is contraindicated in dogs with thyrotoxicosis, acute myocardial infarction and uncorrected adrenal insufficiency. Use in pregnant bitches has not been evaluated. Overdosage can result in thyrotoxicosis. Administer with caution to animals with clinically significant heart disease, hypertension or other complications for which a sharply increased metabolic rate might prove hazardous. 

Please refer to the package insert on the Leventa website for complete product information. 

www.leventa.com/label.asp 

Description
LEVENTA^® is an oral solution for Dogs Each mL of LEVENTA^® (levothyroxine sodium, USP.) oral solution provides 1 mg synthetic crystalline levothyroxine sodium (L-thyroxine). 

Indications
Thyroid replacement therapy in dogs with hypothyroidism. Hypothyroidism is the generalized metabolic disease resulting from deficiency of the thyroid hormones, L-thyroxine (T₄) and triiodothyronine (T₃). LEVENTA^® oral solution will provide L-thyroxine (T₄) as a substrate for the physiologic deiodination to triiodothyronine (T₃). Administration of L-thyroxine (T₄), identical to the L-thyroxine (T₄) secreted endogenously by the normal thyroid gland, will result in complete physiologic thyroid replacement. L-thyroxine (T₄) acts to stimulate metabolism, growth, development and differentiation of tissues. It increases the rate of energy exchange and the maturation rate of the epiphyses. The clinical diagnosis of hypothyroidism should be completed by evaluation of the thyroid hormone of the dog, i.e., measurement of serum levels of total (or preferably free) thyroxine (T₄) and thyroid stimulating hormone (TSH). A low total (or free) T₄ concentration combined with high TSH concentration is strongly suggested for primary hypothyroidism. 

Administration and Dosage
The adequate dose rate has to be defined individually for each dog. Treatment should be initiated at a recommended dose rate of 20 µg L-thyroxine/kg once daily and re-evaluated every four weeks by monitoring T₄ serum levels four to six hours post-treatment. According to the T₄ levels, the veterinarian will decide to adjust the dose rate if needed. Once the dosage suitable to resolve the hypothyroidism clinical and hormonal condition of the dog is determined (maintenance dosage), serum T₄ levels four to six hours post-treatment should be checked every six months. The usual maintenance dosage is 20 µg L-thyroxine/kg once daily.

Caution
The effects of L-thyroxine therapy are slow to manifest. Overdosage of any thyroid drug may produce the signs and symptoms of thyrotoxicosis including, but not limited to: polydipsia, polyuria, polyphagia, reduced heat tolerance and hyperactivity or personality change. Administer with caution to animals with clinically significant heart disease, hypertension or other complications for which a sharply increased metabolic rate might prove hazardous. 

L-thyroxine therapy is contraindicated in thyrotoxicosis, acute myocardial infarction and uncorrected adrenal insufficiency. Use in pregnant bitches has not been evaluated. 

Supplied
LEVENTA^® oral solution (L-thyroxine 1 mg/mL) is available in 30 mL bottles closed with childproof caps. Each bottle is provided with a 1 mL dosing syringe to be used for administration. 

STORAGE INFORMATION: Store refrigerated at 2—8°C (37—46°F), protect from light. After first opening, store at room temperature 20—25°C (68—77°F) and use within 2 months. 


KEEP OUT OF THE REACH OF CHILDREN. 

FOR ANIMAL USE ONLY 

Product Label(s) and MSDS: http://www.compasnac.com/intervet.htm

For more information about Intervet Products call 1-800-441-8272.