Vetsulin^® (porcine insulin zinc suspension) is the first and only FDA-approved insulin available in the USA for treating diabetic dogs. 

Vetsulin should not be used in dogs known to have a systemic allergy to pork or pork products. Vetsulin is contraindicated during periods of hypoglycemia. Keep out of the reach of children. Animals presenting with severe ketoacidosis, anorexia, lethargy, and/or vomiting should be stabilized with short-acting insulin and appropriate supportive therapy until their condition is stabilized. As with all insulin products, careful patient monitoring for hypoglycemia and hyperglycemia are essential to attain and maintain adequate glycemic control and associated complications. Overdosage can result in profound hypoglycemia and death. 

See the package insert on the Vetsulin web site for full information regarding contraindications, warnings and precautions. 

www.vetsulin.com/Veterinarian/prod-label.html 

pH is adjusted with hydrochloric acid and/or sodium hydroxide. 

Indications
Vetsulin^® (porcine insulin zinc suspension) is indicated for the reduction of hyperglycemia and hyperglycemia-associated clinical signs in dogs with diabetes mellitus.

Administration and Dosage
USE OF A SYRINGE OTHER THAN A U-40 SYRINGE WILL RESULT IN INCORRECT DOSING. FOR SUBCUTANEOUS INJECTION IN DOGS ONLY. 

Vetsulin^® should be mixed by gentle rolling of the vial prior to withdrawing the dose from the vial. Using a U-40 insulin syringe, the injection should be administered subcutaneously, 2 to 5 cm (3/4 to 2 in) from the dorsal midline, varying from behind the scapulae to the mid-lumbar region and alternating sides.

The initial recommended Vetsulin dose is 1 IU insulin/kg body weight plus a body weight-dependent dose supplement as shown in the table below.

Caution
Animals presenting with severe ketoacidosis, anorexia, lethargy, and/or vomiting should be stabilized with short-acting insulin and appropriate supportive therapy until their condition is stabilized. As with all insulin products, careful patient monitoring for hypoglycemia and hyperglycemia are essential to attain and maintain adequate glycemic control and associated complications. Overdosage can result in profound hypoglycemia and death. Progestogens, certain endocrinopathies and glucocorticoids can have an antagonistic effect on insulin activity. Intact bitches should be ovariohysterectomized. Progestogen and glucocorticoid use should be avoided. 

Drug Interactions: In the US clinical effectiveness study, dogs received various medications while being treated with Vetsulin^® including antimicrobials, NSAIDs, thyroid hormone supplementation, internal and external parasiticides, anti-emetics, dermatological topical treatments and oral supplements, and ophthalmic preparations containing antimicrobials and antiinflammatories. No medication interactions were reported. This drug was not studied in dogs receiving steroids. 

Reproductive Safety: The safety and effectiveness of Vetsulin in breeding, pregnant, and lactating dogs has not been evaluated. 

Use in puppies: The safety and effectiveness of Vetsulin in puppies has not been evaluated.         

Supplied
Vetsulin^® is supplied as a sterile injectable suspension in multidose vials containing either 2.5 mL or 10 mL of 40 IU/mL porcine insulin zinc suspension. Vials are supplied in cartons of one, 10 mL vial and cartons of ten, 2.5 mL vials. 

Product Label(s) and MSDS: http://www.compasnac.com/intervet.htm

For more information about Intervet Products call 1-800-441-8272.