PROGARD^®-8 is a modified live virus vaccine containing attenuated strains of canine distemper virus, adenovirus type 2, parainfluenza virus, and parvovirus grown in the PRO-CELL STABLE CELL LINE^TM. PROGARD^®-8 is presented in a desiccated form with inactivated canine corona virus Leptospira canicola and Leptospira icterohaemorrhagiae bacterin as the diluent. 

The attenuated distemper virus strain used in PROGARD^®-8 is the Onderstepoort strain. The parvovirus component is patented* CPV Strain 154^® which is an attenuated parvovirus strain of canine origin. The unique InterTek^TM production process has made it possible to produce PROGARD^®-8 with high titered CPV and CDV components which are highly immunogenic. 

The Manhattan strain of adenovirus type 2 in PROGARD^®-8 confers protection against canine infectious hepatitis caused by CAV-1 as well as CAV-2. Use of the Manhattan strain of CAV-2 provides dual protection without the adverse reactions associated with CAV-1, such as corneal edema ("blue eye").

The safety, efficacy and compatibility of each of the components of PROGARD^®-8 has been demonstrated to meet or exceed the standards set forth by the U.S.D.A. Extensive safety testing has demonstrated that CPV STRAIN 154^® and the CDV components are safe when given to puppies as young as four weeks of age.

Indications
PROGARD^®-8 is for vaccination of healthy dogs against canine distemper virus, canine infectious hepatitis caused by CAV-1, canine respiratory infection caused by CAV-2, canine parainfluenza virus, canine parvovirus and leptospirosis caused by L. canicola and L. icterohaemorrhagiae. 

Administration and Dosage
Aseptically reconstitute the desiccated vaccine vial with the combined canine coronavirus-Leptospira spp bacterin provided and administer 1 mL by subcutaneous route. Initial vaccination of healthy dogs may be given as early as six weeks of age with booster injections administered every 3-4 weeks until 12 weeks of age. Dogs over 12 weeks of age should receive two doses 3-4 weeks apart. Annual revaccination with a single dose is recommended. 

Caution

1. Recommended storage temperature 35-45^oF (2-7^oC). Do not freeze. 
2. Shake well before use. 
3. Use contents promptly once reconstituted. 
4. Non-chemically sterilized needles and syringes should be used for administration of vaccine. 
5. Avoid vaccinating pregnant bitches. 
6. Contains gentamicin as a preservative. 
7. Burn this container and all unused contents. 
   Only healthy animals should be vaccinated. Animals incubating any disease, or animals stressed due to shipping, malnutrition or parasitism may not achieve or maintain an adequate immune response. 
8. This product is not hazardous when used according to directions supplied. A material safety data sheet (MSDS) is available upon request. 

Antidote
Administration of epinephrine may be indicated in the event of an anaphylactic reaction.

Supplied
Code: C-675-1
Cartons of 25x1-dose desiccated vaccine vials and 25x1-dose
Inactivated canine coronavirus-Leptospira canicola and Leptospira icterohaemorrhagiae combined bacterin vials as diluent.

Product Label(s) and MSDS: http://www.compasnac.com/intervet.htm

For more information about Intervet Products call 1-800-441-8272.