GUARDIAN E. COLI VACCINE

Therapeutic Class

Pharmaceutical Name
Biological Name: Escherichia Coli Bacterin

Features and Benefits
20th Century Technology - Whole-Cell E. coli Vaccine

Harmful and potentially fatal endotoxins exist in E. coli cells.
Despite manufacturing processes, endotoxins still exist in whole-cell E. coli vaccines.

21st Century Technology - Subunit E. coli Vaccine

Guardian’s sub-unit technology yields a vaccine containing a concentrated subunit K99 pilus antigen.
- Immune response is targeted to this antigen.
This process reduces the amount of E. coli endotoxin in the vaccine.

The Risks from E. coli Endotoxin¹

The effects of E. coli endotoxin can range from inflammation to irreversible shock and death.
One of the greatest economic risks from E. coli endotoxin in pregnant cattle is abortion.

E. coli Subunit Technology for Effective and Safe Bacterial Protection

E. coli K99 Challenge with Heterologous Strain

Calves nursing Guardian-vaccinated heifers were protected against E. coli challenge.
These calves scored lower on depression and composite clinical factors, and experienced a dramatically lower mortality

Guard Your Baby Calves with the Single-Dose, Most Advanced Scours Vaccine

Target Animals	Dosage & Route	Primary Vaccination	Annual Revaccination	Bottle Sizes	Preslaughter Withdrawal
Pregnant heifers & cows	2 mL SC	Single dose 3 months pre-calving	Single dose 5-7 weeks pre-calving	20 mL (10 doses)100 mL (50 doses)	60 days

¹Adapted from Tizard, IR. Lymphokines and Cytokines. In Veterinary Immunology: An Introduction, 4th Ed. WB Saunders Company, 1992.

Dosage
For further information including dose rate and complete directions and warnings, please see the Product Label by clicking here.

Guardian^® E. coli Vaccine is a registered trademark of Schering-Plough Animal Health Corporation.